Anna,

I was not part of any trial, in fact I'm Type 2. Some friends from India brought me a two-pack and I tested it out. It was more experimental since I had limited supply. I basically used 2-3 puffs when my BG was too high and it brought it down rather quickly.

There is a protocol to use it for post-prandial spikes but that requires a lot more puffs, which I didn't want to use.

But, overall, I found it incredibly convenient and effective for lowering BG quickly. Here's a few comments from a Generex Forum Type 1 user:

Wow, it works although you would need quite a few sprays if you planned to eat loads of carb for one meal or if if your blood sugar level was a bit elevated. For myself I have found that 1 spray is all I need to handle 20 grams of carb on a lowish blood sugar level.

Oral-lyn's action is very fast and I have found that its duration is virtually over within 3 hours. I don't need to snack at all which is great really. On u100 rapid acting insulin I would need about 4 units to handle 20 grams of carb whereas with Oral-lyn it's only 1 or 2 sprays depending on what my blood sugar levels are.

LarryD - just curious - how did you find your BG's during the 2 week trial using the Oral Recosulin?  Did you have to use a basal insulin during the time period and only use the oral insulin for meals?  So many questions, and I'm excited to hear from someone who has had the chance to try it out (wish I'd been part of the test group!).  Glad to hear that there is no strange after taste, as that could put some people off (not myself, if it meant no more needles).

Hoopster - thanks for the heads up on the approval for Oral-lyn here in Canada.  I'm going to see my endo in a few weeks (we've not seen each other since I went to the IDF Congress back in October).  I have lots of info to give to him that I had collected on diabetes (hope he has time set aside rather then his regular 20 minutes ).  I'll bring along the Oral-lyn "demo" that I have in the picture here - see what his expression is as I "inhale".

Meanwhile, I've done abit of research at Health Canada for the SAP (Special Access Program) - and not having much luck finding what you've found.  If you've got the link, feel free to post it here if you want, so we "wanna be doctors" can look into it. 

Anna, in case you are not aware. Health Canada has approved Ora-lyn under its Special Access Program.  To the best of my knowledge multiple patients with needle phobias and other problems that prevent their use of injectable insulin have taken advantage of this program.  I am in the US, so I assume you would need to get a prescription and/or request from your physician and submit it to Health Canada.

Similarly, Ora-lyn has been approved in the US under the FDA's Investigational New Drug Program and approval is similarly granted.

Good luck to you and please update us if you are successful in accessing Ora-lyn through the SAP.

I had the opportunity to use Oral-Lyn (Oral Recosulin from India) for a few weeks and their is no objectional taste other than a slight aftertaste. It is not inhaled, but rather absorbed directly in the cheek mucosa. Should be a big hit when it finally comes to market in the US.

Hmm.. personally, I would imagine it would be similar to how an inhaler (for asthmatics) tastes like.. I haven't personally tried or had the pleasure of smelling either, but I hardly ever find medicine to be pleasant in any way, shape, or form.. LOL

Though maybe they'll have flavored versions of the Oral-Lyn like they do for the RapidSpray.. That coupled with the DS game for kids might really help motivate children to better manage their diabetes.. hehe

Here's a picture we took this morning of my "using" the Oral-lyn™.  Remember, this is only the squeezy stress toy they gave to me - but still imagine not having to inject your insulin - but inhale it instead.  Tho' wonder what kind of taste would be left in your mouth?  Insulin smells wierd to begin with, have never actually dipped my finger into it, and tasted it (have you?). Ugh.